Expanding biotransformations: Several metal‐binding noncanonical amino acids have been incorporated into protein scaffolds to create artificial metalloenzymes. We introduced 2‐amino‐3‐(8‐hydroxyquinolin‐3‐yl)propanoic acid (HQAla) into lactococcal multidrug‐resistance regulator (LmrR) and complexed it with several transition metal ions such as Cu^II, Zn^II and Rh^III to showcase its catalytic potential in a variety of different reactions.

中文翻译：

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用于设计新型人造金属酶的基于羟基喹啉的非天然氨基酸。

扩大生物转化：几种金属结合的非规范氨基酸已被纳入蛋白质支架中以产生人造金属酶。我们将 2-氨基-3-(8-羟基喹啉-3-基)丙酸 (HQAla) 引入乳球菌多药耐药调节剂 (LmrR) 中，并将其与几种过渡金属离子（如 Cu II ^、 Zn ^II和 Rh ^III ）络合，展示其在各种不同反应中的催化潜力。