Impedance has traditionally been employed in esophageal disease as a means to assess bolus flow and reflux episodes. Recent and ongoing research has provided new and novel applications for this technology. Measurement of esophageal mucosal impedance, via either multichannel intraluminal impedance catheters or specially designed endoscopically deployed impedance catheters, provides a marker of mucosal integrity. Mucosal impedance has been shown to segregate gastroesophageal reflux disease (GERD) and eosinophilic esophagitis from non‐GERD controls and may play a role in predicting response to reflux intervention. More data are needed with regard to other esophageal subgroups, outcome studies, and functional disease. Our paper reviews the history of impedance in esophageal disease, the means of assessing baseline and mucosal impedance, data with regard to the newly developed mucosal impedance probes, the clinical utility of mucosal impedance in specific clinical conditions, and limitations in our existing knowledge, along with suggestions for future studies.

中文翻译：

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食管疾病的黏膜阻抗：评估证据

阻抗传统上被用于食管疾病作为评估丸流和反流发作的手段。最近和正在进行的研究为这项技术提供了新的和新颖的应用。通过多通道腔内阻抗导管或专门设计的内窥镜部署阻抗导管测量食管粘膜阻抗，提供了粘膜完整性的标志。黏膜阻抗已被证明可以将胃食管反流病 (GERD) 和嗜酸性粒细胞性食管炎与非 GERD 对照区分开来，并且可能在预测对反流干预的反应方面发挥作用。需要更多关于其他食管亚组、结果研究和功能性疾病的数据。我们的论文回顾了食管疾病阻抗的历史，评估基线和粘膜阻抗的方法，