Nanoengineered Light-Activatable Polybubbles for On-Demand Therapeutic Delivery.,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Nanoengineered Light-Activatable Polybubbles for On-Demand Therapeutic Delivery.
Advanced Functional Materials ( IF 19.0 ) Pub Date : 2020-06-26 , DOI: 10.1002/adfm.202003579
Shreedevi Arun Kumar ₁ , Jacob Good ₁ , David Hendrix ₁ , Eunsoo Yoo ₂ , Dongin Kim ₂ , Kaivalya A Deo ₁ , Yong-Yu Jhan ₁ , Akhilesh K Gaharwar _{1,

3,

4} , Corey J Bishop ₁

Affiliation

Vaccine coverage is severely limited in developing countries due to inefficient protection of vaccine functionality as well as lack of patient compliance to receive the additional booster doses. Thus, there is an urgent need to design a thermostable vaccine delivery platform that also enables release of the bolus after predetermined time. Here, the formation of injectable and light‐activatable polybubbles for vaccine delivery is reported. In vitro studies show that polybubbles enable delayed burst release, irrespective of cargo types, namely small molecule and antigen. The extracorporeal activation of polybubbles is achieved by incorporating near‐infrared (NIR)‐sensitive gold nanorods (AuNRs). Interestingly, light‐activatable polybubbles can be used for on‐demand burst release of cargo. In vitro, ex vivo, and in vivo studies demonstrate successful activation of AuNR‐loaded polybubbles. Overall, the light‐activatable polybubble technology can be used for on‐demand delivery of various therapeutics including small molecule drugs, immunologically relevant protein, peptide antigens, and nucleic acids.

更新日期：2020-08-03

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>