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Developing a new chemosensor targeting zinc ion based on two types of quinoline platform.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.4 ) Pub Date : 2020-06-26 , DOI: 10.1016/j.saa.2020.118652
Ahran Kim 1 , Hangyul Lee 1 , Dongju Yun 1 , Ukhyun Jung 2 , Ki-Tae Kim 2 , Cheal Kim 1
Affiliation  

A chemosensor DQ (2-(2-(quinolin-2-yl)hydrazinyl)-N-(quinolin-8-yl)acetamide), based on two quinoline moieties, has been synthesized. DQ could detect zinc ion through fluorescence turn-on in aqueous media. Limit of detection was calculated as 0.07 μM, far lower than the standard of WHO for zinc ion. The practicality of DQ was demonstrated via the successful results of reusability with EDTA, easy detection on the test strip, and precise quantification in real water samples. Additionally, sensor DQ could be applied to bioimaging of zinc ion in zebrafish. Sensing process of zinc ion by DQ was studied through fluorescence and UV–Vis spectroscopy, 1H NMR titration, and ESI-mass spectrometry.



中文翻译:

开发基于两种喹啉平台的靶向锌离子的新型化学传感器。

合成了基于两个喹啉基团的化学传感器DQ(2-(2-(喹啉-2-基)肼基)-N-(喹啉-8-基)乙酰胺)。DQ可以通过在水性介质中打开荧光来检测锌离子。计算的检出限为0.07μM,远低于WHO对锌离子的标准。DQ的实用性通过EDTA可重用性,在试纸上易于检测以及在真实水样中进行精确定量的成功结果得到了证明。此外,传感器DQ可应用于斑马鱼中锌离子的生物成像。通过荧光和紫外-可见光谱研究了DQ对锌离子的传感过程,11 H NMR滴定和ESI质谱。

更新日期:2020-07-02
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