Using UV–Vis, FT-IR, fluorescence spectroscopy and protein-ligand docking, the interactions between the zinc complexes with drug analogues and bovine serum albumin were investigated. In addition, considering the ubiquitous presence of zinc ions in the human system, we studied the interactions between this ion with hymecromone, dihydropyridine analogue, and acetamide, as well as the pH influence on these systems. The complexes were synthesized by interaction between the ligands and the Zn (II) ion in a 2:1 M ratio. Elemental analysis, FT-IR, and UV–Vis spectroscopy studies investigated the structure of the synthesized complexes. Fluorescence spectroscopy, UV–Vis, molecular docking and molecular dynamics were used to study the interactions of the Zn complexes with the BSA. The drug-Zn (II) system's pH effect was investigated using UV–Vis spectroscopy. After the complexation with the zinc, the drug molecules exhibited higher apparent binding affinity to BSA. BSA's fluorescence efficiency by the drug analogues was enhanced. In addition, molecular modelling was used to classify the residue of amino acids in the BSA playing key roles in this binding interaction. An increase in pH appears to contribute to alkaline hydrolysis of the Zn (II) molecules.

使用紫外可见光，红外光谱，荧光光谱和蛋白质-配体对接，研究了锌配合物与药物类似物和牛血清白蛋白之间的相互作用。此外，考虑到人体系统中普遍存在的锌离子，我们研究了该离子与羟考酮，二氢吡啶类似物和乙酰胺之间的相互作用，以及pH对这些系统的影响。通过配体与Zn（II）离子之间以2：1 M的比例相互作用来合成配合物。元素分析，FT-IR和UV-Vis光谱研究研究了合成配合物的结构。荧光光谱，UV-Vis，分子对接和分子动力学用于研究锌配合物与BSA的相互作用。药物锌（II）系统' 使用紫外可见光谱法研究了其pH效应。与锌络合后，药物分子对BSA表现出更高的表观结合亲和力。药物类似物增强了BSA的荧光效率。另外，使用分子模型对BSA中的氨基酸残基进行分类，从而在这种结合相互作用中发挥关键作用。pH值的升高似乎有助于Zn（II）分子的碱性水解。