Abstract In this work, a multi-layer wound dressing consisting of polyvinyl alcohol (PVA) foam and electrospun sodium carboxymethylcellulose (CMC) surface mesh was developed and characterized. Antimicrobial drug stearyl trimethyl ammoium chloride (STAC) was loaded into the PVA foam for infection control and the CMC surface mesh offers effective hemostatic function. Additionally, the potential of laser photodynamic response of the loaded methylene blue (MB) and its effect in enhancing the wound dressing's bacterial inhibition has been investigated. The antibacterial drug and laser photodynamic therapy (PDT) were jointly deployed, which demonstrated greater potential in killing both S. aureus and E. coli bacteria strains. In addition, the unique color changing property of MB has enabled real time bacterial infection monitoring of the wound dressing. The multi-layer wound dressing with ideal material combination and unique multifunctionality may be a promising option for wound management in the future healthcare sector.

中文翻译：

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智能多层 PVA 泡沫/CMC 网状敷料，集成多功能，用于伤口管理和感染监测

摘要 在这项工作中，开发并表征了一种由聚乙烯醇 (PVA) 泡沫和电纺羧甲基纤维素钠 (CMC) 表面网组成的多层伤口敷料。将抗菌药物硬脂酰三甲基氯化铵 (STAC) 装入 PVA 泡沫中以控制感染，CMC 表面网提供有效的止血功能。此外，还研究了负载亚甲蓝 (MB) 的激光光动力响应的潜力及其在增强伤口敷料细菌抑制方面的作用。抗菌药物和激光光动力疗法（PDT）联合部署，显示出更大的杀死金黄色葡萄球菌和大肠杆菌菌株的潜力。此外，MB 独特的变色特性使伤口敷料的细菌感染实时监测成为可能。具有理想材料组合和独特多功能性的多层伤口敷料可能是未来医疗保健领域伤口管理的一个有前景的选择。