B lymphocytes have well-established effector roles during viral infections, including production of antibodies and functioning as antigen presenting cells (APC) for CD4 + and CD8 + T cells. B cells have also been shown to regulate immune responses and induce regulatory T cells (Tregs). In the Friend virus (FV) model, Tregs are known to inhibit effector CD8 + T cell responses and contribute to virus persistence. Recent work has uncovered a role for B cells in the induction and activation of Tregs during FV infection. In addition to inducing Tregs, B cell antibody production and APC activity is a target of Treg suppression. This review focuses on the dynamic interactions between B cells and Tregs during FV infection.

B淋巴细胞在病毒感染期间具有公认的效应子作用，包括产生抗体并充当CD4 +和CD8 + T细胞的抗原呈递细胞（APC）。还显示出B细胞可调节免疫反应并诱导调节性T细胞（Tregs）。在Friend病毒（FV）模型中，已知Treg可抑制效应CD8 + T细胞反应并有助于病毒持久性。最近的工作已发现B细胞在FV感染过程中诱导和激活Treg的作用。除了诱导Treg，B细胞抗体的产生和APC活性也是Treg抑制的目标。这篇综述着重于FV感染期间B细胞与Treg之间的动态相互作用。