Abstract The introduction of a continuous crystallization process has been attracting attention for the pharmaceutical products. We designed a novel continuous crystallizer, which includes Couette–Taylor equipment integrated with MSMPR equipment in a cascading manner. Additionally, feed solutions were supplied to MSMPR and Couette–Taylor equipment to flexibly control the supersaturation of the MSMPR equipment, regardless of the supersaturation of Couette–Taylor equipment. In this study, the relationship between operating parameters in novel cascade–type crystallizer and final crystal quality was investigated. We found that the quality of the obtained crystalline particles depend on the flow-rate ratio of the feed solution supplied to Couette–Taylor equipment. Furthermore, the yield of crystalline products was improved using proposed crystallizer. Therefore, we expect proposed novel cascade–type crystallizer consisting of Couette–Taylor and MSMPR equipment to obtain crystalline products with various quality.

中文翻译：

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连续生产结晶颗粒的新型级联式结晶器的研制

摘要 连续结晶工艺的引入引起了医药产品的关注。我们设计了一种新型连续结晶器，其中包括以级联方式与 MSMPR 设备集成的 Couette-Taylor 设备。此外，向MSMPR 和Couette-Taylor 设备提供进料溶液，以灵活控制MSMPR 设备的过饱和度，而不管Couette-Taylor 设备的过饱和度如何。在这项研究中，研究了新型级联结晶器的操作参数与最终晶体质量之间的关系。我们发现获得的结晶颗粒的质量取决于提供给 Couette-Taylor 设备的进料溶液的流速比。此外，使用建议的结晶器提高了结晶产物的产率。