Abstract

A method has been developed for the preparation of a new type of dispiro derivative, 5''-bromo-2-[(4-chlorophenyl)sulfanyl]-1'-methyl-1,4'-diphenyldispiro[imidazole-4,3'-pyrrolidine-2',3''-indoline]-2'',5(1H)-dione, starting from 2-thiohydantoin and using a 1,3-dipolar cycloaddition reaction. The configuration of the target dispiro derivative was unambiguously established by physicochemical methods.

中文翻译：

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2-硫代乙内酰脲的新型S-酰化双螺衍生物

摘要

已开发出一种用于制备新型双螺衍生物的方法，即5''-溴-2-[（（4-氯苯基）硫烷基] -1'-甲基-1,4'-二苯基二螺[咪唑-4,3） '-吡咯烷-2'，3''-二氢吲哚] -2''，5（1 H）-二酮，从2-巯基乙内酰脲开始，并使用1,3-偶极环加成反应。通过物理化学方法明确地确定了目标双螺衍生物的构型。