Abstract

This review addresses the use of poly(ethylene glycol) (PEG) and PEG conjugation for the design of novel dosage forms and the modification of biomolecules. The peculiarities of PEGylated nanoparticles, liposomes, proteins, enzymes, and small drug and polyelectrolyte molecules and their influence on systemic drug delivery, including overcoming of various biological barriers and adhesion to mucosal tissues (mucoadhesion), are considered.

中文翻译：

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药物中的聚乙二醇化系统

摘要

这项审查解决了使用聚（乙二醇）（PEG）和PEG共轭设计新剂型和生物分子的修饰。考虑了聚乙二醇化的纳米颗粒，脂质体，蛋白质，酶，小分子药物和聚电解质分子的特性及其对全身药物传递的影响，包括克服了各种生物学障碍和对粘膜组织的粘附（粘膜粘附）。