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Nanotechnologies for enhancing cancer immunotherapy
Nano Research ( IF 9.9 ) Pub Date : 2020-06-26 , DOI: 10.1007/s12274-020-2904-8
Jingxian Yang , Chunhui Wang , Shuo Shi , Chunyan Dong

Immunotherapy, a burgeoning field differs from traditional cancer treatments, is revolutionizing oncologic therapeutics. It aims to stimulate the innate and adaptive immune system of a patient to fight against tumor cells. However, low response rate and immune-related adverse effects (irAEs) remain problems during its management. A novel technology using nanomaterials may bring a solution. Various nanoparticles have been investigated as delivery systems to augment cancer therapeutic efficacy in the lab and clinic. In this review, we briefly summarize the connotation of immunotherapy, the application of nanotechnology in cancer, especially focusing on the synergistic effect of nanoplatform-based technology combined with cancer immunotherapy, hoping to make readers a deep insight into this interdisciplinary field.



中文翻译:

纳米技术可增强癌症免疫疗法

新兴的免疫疗法领域不同于传统的癌症疗法,它正在彻底改变肿瘤疗法。它旨在刺激患者的先天性和适应性免疫系统以对抗肿瘤细胞。然而,低应答率和免疫相关的不良反应(irAEs)仍然是治疗过程中的问题。使用纳米材料的新技术可能带来解决方案。在实验室和临床中已经研究了各种纳米颗粒作为递送系统以增强癌症的治疗功效。在这篇综述中,我们简要总结了免疫疗法的内涵,纳米技术在癌症中的应用,特别是关注基于纳米平台的技术与癌症免疫疗法的协同作用,希望使读者对这一跨学科领域有更深入的了解。

更新日期:2020-06-26
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