Backgrounds

Recent research has shown that stress has a significant influence on the functions of many organs.

Objective

The present study investigated the effect of acute or chronic restraint stress on physiological and psychological processes.

Results

In the acute stress group, body weight and food intake did not change, but in the chronic stress group, food intake significantly increased and body weight was significantly inhibited. ALT and AST levels were significantly increased by both groups. Acute and chronic restraint stress led to different behavioral changes. Serum levels of corticosterone and cortisol were more increased in chronic stress than in acute stress. The levels of neurons and astrocyte in the hippocampus, and the NeuN-positive neuronal cells remained unaffected by acute stress, but were decreased by chronic stress. GFAP-positive astrocytes were increased by both groups.

Conclusion

In summary, our study provides evidence of a relationship between liver injury and behavioral change upon exposure to restraint stress.

中文翻译：

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小鼠急慢性应激神经行为改变与肝损伤的比较分析

背景资料

最近的研究表明，压力会对许多器官的功能产生重大影响。

目的

本研究调查了急性或慢性束缚应激对生理和心理过程的影响。

结果

在急性应激组中，体重和食物摄入量没有变化，但是在慢性应激组中，食物摄入量显着增加，体重被显着抑制。两组的ALT和AST水平均显着升高。急性和慢性束缚压力导致不同的行为改变。与慢性应激相比，慢性应激的血清皮质酮和皮质醇水平增加更多。海马中神经元和星形胶质细胞的水平以及NeuN阳性神经元细胞不受急性应激的影响，但受慢性应激的影响而降低。两组的GFAP阳性星形胶质细胞均增加。

结论

总而言之，我们的研究提供了暴露于约束性应激时肝损伤与行为改变之间关系的证据。