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The acrid raphides in tuberous root of Pinellia ternata have lipophilic character and are specifically denatured by ginger extract.
Journal of Natural Medicines ( IF 3.3 ) Pub Date : 2020-06-26 , DOI: 10.1007/s11418-020-01425-6
Tsukasa Fueki 1, 2, 3 , Koichiro Tanaka 2 , Kunihiko Obara 2, 4 , Ryudo Kawahara 2, 5 , Takao Namiki 6 , Toshiaki Makino 3
Affiliation  

Unprocessed dried tuberous root of Pinellia ternata (Pinellia Tuber) has been used as a component of traditional Japanese Kampo medicine, while this crude drug is usually used after processing with Ginger in traditional Chinese medicine (TCM). It is known that the raphides contained in unprocessed Pinellia Tuber can induce severe acrid irritation of the oral and laryngopharynx mucosa when it is boiled insufficiently. However, the mechanism of the inducing irritation by the raphides nor that of the detoxification by heat or processing with Ginger have been left unclear, mainly because of the difficulties in the extraction and the purification of the raphides and in the assays of acridity. In this study, we developed an easy protocol that can be used to collect raphides from unprocessed Pinellia Tuber and an assay protocol that can be used to evaluate the acridity of the raphides in vitro. The raphides of Pinellia Tuber were discovered to have a lipophilic character and to be collected easily by the extraction using petroleum ether. It was also found that the denaturation of the raphides could be assayed by the dispersity of them in petroleum ether layer of the water/petroleum ether partition, and the acridity of the raphides was found to be in correlation with the assayed denaturation. The raphides were denatured by heat, methanol, or Ginger extract and the denaturing activity of Ginger on raphides was found to be attributable to its lipophilic and thermostable components, which may explain the meaning of the processing of Pinellia Tuber with Ginger in TCM, and may lead to the development of an easier and safer protocol to administer Pinellia Tuber. In addition, it was found that rinsing the mouth with salad oil can effectively relieve irritation of the oral mucosa caused by unprocessed Pinellia Tuber, probably due to the lipophilicity of the raphides.

Graphic abstract



中文翻译:

半夏块根中的辣根具有亲脂性,经生姜提取物特异性变性。

半夏未加工干燥块根(半夏)已被用作日本传统汉方药的成分,而这种生药通常在中药(TCM)中与生姜一起加工后使用。众所周知,未经加工的半夏块茎中所含的针叶碱在煮沸不足时会引起口腔和喉咽粘膜的严重刺激。然而,由于刺梨的提取和纯化以及辛辣度的测定存在困难,因此刺梨刺激性的机制以及生姜加热解毒或加工解毒的机制尚不清楚。在这项研究中,我们开发了一个简单的协议,可用于从未加工的半夏块茎中收集 raphides,以及一个可用于评估 raphides 体外辛辣度的分析协议。发现半夏块茎的 rapides 具有亲脂性,并且很容易通过使用石油醚提取来收集。还发现,可以通过它们在水/石油醚分区的石油醚层中的分散性来测定针晶的变性,并且发现针晶的辛辣度与测定的变性相关。生姜经热、甲醇或生姜提取物变性,生姜对生姜的变性活性归因于其亲脂性和热稳定性成分,这可能解释了半夏用生姜加工的意义,并可能导致开发更容易和更安全的协议来管理半夏块茎。此外,

图形摘要

更新日期:2020-06-26
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