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A piezoelectric bone fixation plate for in vivo application and monitoring of mechanical loading during fracture healing
Measurement Science and Technology ( IF 2.4 ) Pub Date : 2020-06-25 , DOI: 10.1088/1361-6501/ab8c6c
Bradley D Nelson , Salil Sidharthan Karipott , Robert E Guldberg , Keat Ghee Ong

Fracture non-union, the failure of a bone fracture to bridge, occurs in roughly 5%–10% of treated fractures and requires lengthy and expensive follow-up interventions. A significant body of research has investigated the efficacy of low-magnitude, high-frequency (LMHF) vibration as a treatment for femoral non-unions through the use of whole-body vibration. This work presents a novel piezoelectric fixation plate for investigating the efficacy of LMHF treatment by applying loads directly to the fracture site, thus reducing undesired systemic effects such as hormonal up-regulation induced by whole-body vibration. The fixation plate can apply mechanical loading in the LMHF regime and monitor the mechanical environment at the fracture site during ambulation to quantify progressive changes in callus stiffness over time as an indication of healing. Mechanical testing demonstrated the ability of the plate to provide displacements of up to 10 µm, as well as to estimate the changing stiffness of the fracture environment.

中文翻译:

一种压电骨固定板,用于骨折愈合过程中机械负荷的体内应用和监测

骨折不愈合(骨折无法桥接)发生在大约 5% 到 10% 的治疗骨折中,需要长时间且昂贵的后续干预。大量研究调查了低幅度、高频 (LMHF) 振动通过使用全身振动治疗股骨骨不连的功效。这项工作提出了一种新型压电固定板,用于通过将负载直接施加到骨折部位来研究 LMHF 治疗的功效,从而减少不良的全身效应,例如全身振动引起的激素上调。固定板可以在 LMHF 状态下施加机械载荷,并在行走过程中监测骨折部位的机械环境,以量化愈伤组织刚度随时间的渐进变化,作为愈合的指示。
更新日期:2020-06-25
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