Under borrowing hydrogen conditions, NHC–iridium(I) catalyzed the direct or one-pot sequential synthesis of α,α-disubstituted ketones via the alkylation of secondary alcohols with primary alcohols is reported. Notably, the present approach provides a new method for the facile synthesis of α,α-disubstituted ketones and featured with several characteristics, including a broad substrate scope, using easy-to-handle alcohols as starting materials, and performing the reactions under aerobic conditions. Moreover, the selective one-pot formation of β,β-disubstituted alcohols was achieved by the addition of an external hydrogen source to the reaction mixture.

中文翻译：

---

铱催化的仲醇与伯醇的烷基化：一种通往支链酮和醇的途径。

据报道，在借用氢的条件下，NHC-铱（I）催化通过仲醇与伯醇的烷基化直接或一锅法连续合成α，α-二取代的酮。值得注意的是，本方法提供了一种易于合成α，α-二取代酮的新方法，该方法具有多种特征，包括广泛的底物范围，使用易于处理的醇作为起始原料，并在有氧条件下进行反应。此外，通过向反应混合物中添加外部氢源，选择性地一锅形成β，β-二取代的醇。