A hybrid composite of silver nanoparticles (AgNPs) and porous silicon microparticles (pSiMPs) was developed and applied for the computed tomography (CT) scanning of the lungs as an image-guided localization agent. We confirmed the grafting of AgNPs on oxidized pSiMPs template using various analytical equipment, including a scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). The hybrid composite showed a high CT contrast intensity (>1000 HU) that enabled us to produce and view images of the lungs. In addition, it showed the ability to maintain a strong CT signal at the injected area of the rabbit’s lungs, up to an hour, without spreading. The lack of toxicity and immune response indicated that the composite could be fully utilized as a new image-guided localization agent of CT scans for lung cancer surgery.

中文翻译：

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银纳米粒子与多孔硅微粒的混合复合材料，作为图像引导的定位剂，用于肺部CT扫描

银纳米颗粒（AgNPs）和多孔硅微粒（pSiMPs）的混合复合材料被开发出来，并作为图像引导的定位剂用于肺部的计算机断层扫描（CT）扫描。我们使用各种分析设备，包括扫描电子显微镜（SEM），傅里叶变换红外（FTIR）光谱，X射线衍射（XRD）和能量色散X射线光谱（EDS），证实了AgNPs在氧化的pSiMPs模板上的接枝）。混合复合材料显示出高的CT对比强度（> 1000 HU），使我们能够产生和查看肺部图像。此外，它还具有在兔子肺部注射区域保持长达一个小时的强CT信号而不会扩散的能力。