Introduction

The 1st Regional Experts on Infant Vaccination (REIV) meeting generated updated consensus recommendations to improve the control of various major vaccine preventable diseases (VPD) in Latin America.

Areas covered

Workshops highlighted recent changes in immunization schedules within the region, experience of countries incorporating combined acellular pertussis vaccines schedules and parenteral inactivated polio vaccine (IPV). The need to definitively replace oral polio vaccine (OPV) by IPV, and potential benefits of introducing new combined vaccines, were extensively discussed.

Expert opinion

REIV strongly advised immediate adoption of either complete IPV schedules for all Latin America or schedules including at least two initial doses of IPV. Use of fractional doses of intradermally administered IPV (fIPV ID) was not recommended due to lower immunogenicity, lack of evidence on long-term protection, and technical difficulty to implement. Routine pertussis vaccination of pregnant women in addition to health workers of neonatology units and any previously unimmunized parent was encouraged. Administration of HBV vaccine to newborns within the first 24 hours of life, and then at 2, 4, and 6 months, and of a booster dose of conjugate Hib vaccine at age 12 through 15 months, was also recommended. Incorporation of combined vaccines (CV) was considered potentially advantageous.

中文翻译：

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当前拉丁美洲小儿传染病学会（SLIPE）关于婴儿疫苗的区域共识建议。

介绍

第一届婴儿疫苗区域专家（REIV）会议产生了最新的共识性建议，以改善拉丁美洲对各种主要疫苗可预防疾病（VPD）的控制。

覆盖区域

讲习班着重介绍了该地区免疫计划的最新变化，结合无细胞百日咳疫苗联合计划和肠胃外灭活脊髓灰质炎疫苗（IPV）的国家的经验。广泛讨论了用IPV最终取代口服脊髓灰质炎疫苗（OPV）的需求，以及引入新的联合疫苗的潜在好处。

专家意见

REIV强烈建议立即采用整个拉丁美洲的完整IPV时间表或包括至少两次IPV初始剂量的时间表。不建议使用小剂量的皮内注射IPV（fIPV ID），因为其免疫原性较低，缺乏长期保护的证据以及实施技术难度大。除了新生儿科的医务人员和任何先前未接受免疫的父母外，还鼓励孕妇进行常规百日咳疫苗接种。还建议在出生后的头24小时内，然后在2、4和6个月内给新生儿接种HBV疫苗，并建议在12到15个月时加强剂量的结合型Hib疫苗。合并联合疫苗（CV）被认为具有潜在的优势。