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SPRY4-IT1 promotes survival of colorectal cancer cells through regulating PDK1-mediated glycolysis
Animal Cells and Systems ( IF 2.9 ) Pub Date : 2020-06-25 , DOI: 10.1080/19768354.2020.1784274
Shengyuan Liu 1 , Feng Huang 1 , Qing Ye 1 , Yangming Li 1 , Jinhu Chen 1 , Hong Huang 1
Affiliation  

ABSTRACT Colorectal cancer (CRC) becomes the third leading cause of cancer-related deaths worldwide recently. The prognosis of CRC is still poor in decades, and targeted therapy is still a potential effective treatment. Long non-coding RNAs (lncRNAs) could regulate series of cellular functions and developmental processes. LncRNA-SPRY4-IT1 (GenBank ID AK024556) is derived from an intron of the SPRY4 gene, which was highly expressed in melanoma cells and affected the progression of multiple types of cancers. However, the mechanism of SPRY4-IT1 in CRC progression remains unclear. Herein, we found the high level of SPRY4-IT1 in human colorectal cancer (CRC) tissues and cells, and correlated with patients’ prognosis. We further noticed that SPRY4-IT1 regulated CRC cell growth and glycolysis, and promoting PDK1 expression. Our data further confirmed that SPRY4-IT1 regulated CRC progression targeting PDK1. We therefore thought SPRY4-IT1 could serve as a promising molecular target for the treatment of CRC.

中文翻译:

SPRY4-IT1通过调节PDK1介导的糖酵解促进结直肠癌细胞的存活

摘要 结直肠癌 (CRC) 最近成为全球癌症相关死亡的第三大原因。CRC的预后在几十年里仍然很差,靶向治疗仍然是一种潜在的有效治疗方法。长链非编码 RNA (lncRNA) 可以调节一系列细胞功能和发育过程。LncRNA-SPRY4-IT1(GenBank ID AK024556)来源于SPRY4基因的一个内含子,该基因在黑色素瘤细胞中高表达并影响多种癌症的进展。然而,SPRY4-IT1 在 CRC 进展中的机制仍不清楚。在此,我们发现人结直肠癌(CRC)组织和细胞中高水平的 SPRY4-IT1,并与患者的预后相关。我们进一步注意到 SPRY4-IT1 调节 CRC 细胞生长和糖酵解,并促进 PDK1 表达。我们的数据进一步证实,SPRY4-IT1 调节靶向 PDK1 的 CRC 进展。因此,我们认为 SPRY4-IT1 可以作为治疗 CRC 的有希望的分子靶点。
更新日期:2020-06-25
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