Scavenger Receptor Class B Type I is Required for 25-Hydroxycholecalciferol Cellular Uptake and Signaling in Myeloid Cells.,Molecular Nutrition & Food Research

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Scavenger Receptor Class B Type I is Required for 25-Hydroxycholecalciferol Cellular Uptake and Signaling in Myeloid Cells.
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2020-07-08 , DOI: 10.1002/mnfr.201901213
Shirley Tenesaca _{1,

2} , Marcos Vasquez _{1,

2} , Myriam Fernandez-Sendin _{1,

2} , Claudia Augusta Di Trani _{1,

2} , Nuria Ardaiz _{1,

2} , Celia Gomar _{1,

2} , Doina Cuculescu _{1,

2} , Maite Alvarez _{1,

2} , Itziar Otano _{1,

2} , Ignacio Melero _{1,

2,

3,

4} , Pedro Berraondo _{1,

2,

3}

Affiliation

Vitamin D₃ is a critical molecule for the properly controlled activity of the immune system. In myeloid‐derived cells, vitamin D₃ induces the production of the antimicrobial and antitumor peptide cathelicidin. In this study, the mechanism of the entry of 25‐hydroxycholecalciferol (25(OH)D) in myeloid‐derived cells is explored.

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