1567

High‐resolution structures of transient receptor potential vanilloid channels: Unveiling a functionally diverse group of ion channels

Mark K. van Goor, Leanne de Jager, Yifan Cheng and Jenny van der Wijst

The transient receptor potential vanilloid (TRPV) family belongs to a large class of ion channels that are widely expressed and considered as key players in human physiology. Their activity is controlled by a set of essential properties affecting channel activation and inactivation in response to voltage, ligands, or intracellular second messengers. Recent fundamental breakthroughs in the field of structural biology have led to novel molecular insight into these extraordinary membrane proteins. Together with mechanistic views on channel functioning, we can move towards detailed structure‐function relationships that are essential to challenge current channel regulation concepts, and to advance studies on channel diversity and their role in human (patho)physiology. https://onlinelibrary.wiley.com/doi/10.1002/pro.3861

中文翻译：

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1567

瞬时受体电位香草通道的高分辨率结构：揭示功能多样的离子通道组

马克·范·高尔（Mark K.van Goor），莱安娜·德·杰格（Leanne de Jager），郑一凡和詹妮

瞬态受体电位香草醛（TRPV）家族属于一类广泛的离子通道，被广泛表达并被认为是人类生理学中的关键角色。它们的活性受一组影响电压，配体或细胞内第二信使的影响通道激活和失活的基本特性控制。结构生物学领域的最新基本突破已导致对这些非凡膜蛋白的新颖分子洞察。结合对通道功能的机械观点，我们可以转向详细的结构-功能关系，这些结构对挑战当前的通道调节概念，推进对通道多样性及其在人（病理）生理学中的作用的研究至关重要。https://onlinelibrary.wiley.com/doi/10.1002/pro.3861