Selenium is a trace mineral that has antioxidant activities and can influence the immune system. However, antiviral effects of selenium have not been well studies in chickens. Chickens were therefore fed diets supplemented with two levels of two different sources of selenium (organic: selenium enriched yeast; SEY or inorganic: sodium selenite; SS). Chickens in the control groups did not receive supplemental dietary selenium. At 14 and 21 days of age, chickens were vaccinated with an inactivated low pathogenicity avian influenza virus (AIV, subtype H9N2) vaccine and blood samples were collected to determine the level of antibodies using hemagglutination inhibition (HI) and ELISA. At 30 days of age, chickens were also challenged with the same virus and swab samples were collected to assess the amount of virus shedding. Antibody levels, as measured by HI, increased significantly in the chickens that received higher levels of SEY at 16 days post vaccination. ELISA titers for IgM and IgY were higher in selenium supplemented chickens. Comparing to challenged control, virus shedding was lower in organic as wel part of springer science+business l as inorganic selenium treated groups. Therefore, it may be concluded that supplemental dietary selenium could enhance vaccine conferred immunity thereby impacting protection against viral challenge in chickens.

硒是一种微量矿物质，具有抗氧化活性，可以影响免疫系统。但是，硒的抗病毒作用尚未在鸡中进行很好的研究。因此，在日粮中向鸡饲喂了两种水平的两种不同来源的硒（有机：富硒酵母； SEY或无机：亚硒酸钠； SS）。对照组的鸡不接受补充饮食硒。在第14天和第21天，给鸡接种灭活的低致病性禽流感病毒（AIV，H9N2亚型）疫苗，并使用血凝抑制（HI）和ELISA收集血液样本以确定抗体水平。在30日龄时，鸡也受到相同病毒的攻击，并收集了拭子样本以评估病毒的释放量。抗体水平 如通过HI测量，在接种疫苗后16天接受较高SEY水平的鸡中显着增加。补充硒的鸡中IgM和IgY的ELISA滴度较高。与挑战性控制相比，作为无机科学处理组的一部分，有机科学中的有机物病毒释放量较低。因此，可以得出结论，补充饮食中的硒可以增强疫苗赋予的免疫力，从而影响对鸡的病毒攻击的保护。