Effective photothermal therapy (PTT) under low temperature (< 50 °C) and power density (< 0.4 W/cm²) avoiding the damage of skin and normal organs. Here, we report a novel heptamethine cyanine dye-based nanoscale coordination polymer (NCP), Hf-HI-4COOH, as an exceptionally effective photosensitizer for nucleus-targeting low temperature PTT. Hf-HI-4COOH shows strong near-infrared absorption and high photothermal conversion efficiency (39.51 %). Further, it exhibits intrinsic nucleus-targeting property and cell inhibition under low power density in vitro. Moreover, the long blood circulation, high tumor accumulation, and nucleus-targeting contribute to significant inhibition of breast tumors in tumor-bearing mice under low temperature (48 °C) and power density (0.3 W/cm²) without obvious toxicity. In general, we establish a nucleus-targeting Hf-HI-4COOH for enhanced PTT with low temperature and power density.

在低温（<50°C）和功率密度（<0.4 W / cm ²）下进行有效的光热疗法（PTT）可以避免对皮肤和正常器官的损害。在这里，我们报告一种新型的基于七甲胺花青染料的纳米级配位聚合物（NCP）Hf-HI-4COOH，作为针对核靶向低温PTT的异常有效的光敏剂。Hf-HI-4COOH具有很强的近红外吸收能力和较高的光热转换效率（39.51％）。此外，它在低功率密度下在体外具有内在的核靶向特性和细胞抑制作用。此外，在低温（48°C）和功率密度（0.3 W / cm ²）下，长的血液循环，高的肿瘤蓄积量和靶向核的作用显着抑制了荷瘤小鼠的乳腺肿瘤。），无明显毒性。通常，我们建立以核为目标的Hf-HI-4COOH，以增强的PTT，具有较低的温度和功率密度。