Abstract We consider the scheduling problem for biomanufacturing projects that involve multiple tasks and “no-wait” constraints between some of these tasks. The aim is to create schedules that ensure timely delivery of products while enabling schedule revisions to accommodate additional constraints realized during the execution of these projects. We formulate the problem as a mixed-integer linear programming model with the objective of minimizing total tardiness, and propose a dynamic scheduling approach that solves a series of modified mixed-integer linear programming models to revise and improve the schedule. We conduct numerical studies to investigate the performance of this approach and compare its performance to a traditional proactive scheduling approach. In collaboration with biomanufacturing companies, we create a scheduling tool and validate the approach with implementation in an industry setting.

中文翻译：

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生物制造项目的动态资源调度

摘要 我们考虑涉及多个任务和其中一些任务之间的“无等待”约束的生物制造项目的调度问题。目的是制定时间表以确保及时交付产品，同时允许修改时间表以适应在这些项目执行期间实现的额外限制。我们将该问题表述为以最小化总延误为目标的混合整数线性规划模型，并提出了一种动态调度方法，该方法解决了一系列修正的混合整数线性规划模型以修正和改进调度。我们进行数值研究来调查这种方法的性能，并将其性能与传统的主动调度方法进行比较。与生物制造公司合作，