This study focused on the evaluation of any possible relationship of polycyclic aromatic hydrocarbons and their hydroxylated derivatives, originated from different anthropogenic activities, with leukemia via determination of polycyclic aromatic hydrocarbons levels in human blood serum. It attempts to provide a sufficient profile of polycyclic aromatic hydrocarbons and their derivatives in leukemia patients (cases) and healthy donors (controls) in Greece, for which pertinent data is lacking. The determination was applied to 198 serum samples, including cases and controls. Demographic and environmental data, such as age, gender, smoking habits and area of residence were subjected to clustered analysis during the statistical treatment of the results. The results demonstrated a statistically significant difference between cases and controls regarding polycyclic aromatic hydrocarbons concentrations, with phenanthrene, fluorene and acenaphthene being the most abundant compounds (<19 ng mL⁻¹). The same difference was also observed for hydroxylated derivatives measured in cases of acute leukemia and controls, with 1-hydroxy phenanthrene and 1-hydroxy pyrene appearing more enriched, with their median concentrations calculated at 11.3 and 7.6 ng mL⁻¹, respectively. Source apportionment tools were employed for the evaluation of any potential associations among polycyclic aromatic hydrocarbons and several parameters. Molecular diagnostic ratios, applied in the classified data, indicated mainly that polycyclic aromatic hydrocarbons detected particularly in patients from rural sites could be originated from wood, grass or biomass burning. Principal Component Analysis, performed for overall and classified data, indicated a bioaccumulation of high molecular weight polycyclic aromatic hydrocarbons with age and chronic types of leukemia and a possible common origin of these toxic compounds in cases of smokers living in industrial residence areas.

这项研究的重点是通过确定人血清中多环芳烃的含量，评估源自不同人为活动的多环芳烃及其羟基化衍生物与白血病的任何可能关系。它试图在希腊缺乏相关数据的白血病患者（病例）和健康供体（对照）中提供足够的多环芳烃及其衍生物的概况。该测定适用于198份血清样品，包括病例和对照。在对结果进行统计学处理期间，对人口和环境数据（例如年龄，性别，吸烟习惯和居住面积）进行了聚类分析。^-1）。在急性白血病和对照组中，对羟基化衍生物的测量也观察到相同的差异，其中1-羟基菲和1-羟基pyr似乎更富集，其中位浓度分别为11.3和7.6 ng mL ^-1， 分别。来源分配工具用于评估多环芳烃与几个参数之间的任何潜在关联。分类数据中使用的分子诊断率主要表明，尤其是在农村地区的患者中检测到的多环芳烃可能源自木材，草木或生物质燃烧。对总体数据和分类数据进行的主成分分析表明，随着年龄和慢性白血病的类型，高分子量多环芳烃的生物蓄积量以及居住在工业居住区的吸烟者可能产生这些有毒化合物。