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Chirality as a Physical Basis of Hierarchical Periodization of Biomacromolecular Structures
Biophysics Pub Date : 2020-03-01 , DOI: 10.1134/s000635092002013x
E. V. Malyshko , A. R. Murtazina , V. A. Tverdislov

Abstract —A unified system of classification of levels of molecular structures of a living cell as the hierarchy of alternating-sign chiral structures that reflects the physical (thermodynamic/entropic) basis of intramolecular and supramolecular folding is proposed and substantiated. The tendencies for intermolecular chiral correspondences characteristic of the interactions between macromolecules of the same and different types at the corresponding levels of molecular organization (for protein–protein, L–L; for nucleic acids, DNA–RNA, D–D; protein–nucleic acids, L–D; and proteins and nucleic acids with L-lipids of membranes, according to the sign of chirality of the corresponding level of organization of the structure of macromolecules) were identified.

中文翻译:

手性作为生物大分子结构分级周期的物理基础

摘要——提出并证实了一个统一的活细胞分子结构层次分类系统,即反映分子内和超分子折叠的物理(热力学/熵)基础的交替符号手性结构的层次结构。在分子组织的相应水平上,相同和不同类型的大分子之间相互作用的分子间手性对应的趋势(对于蛋白质-蛋白质,L-L;对于核酸,DNA-RNA,D-D;蛋白质-核根据大分子结构的相应组织水平的手性标志,鉴定了具有L-脂质膜的蛋白质和核酸。
更新日期:2020-03-01
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