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Experimental Comparison of the Antitumor Activities of Aurumacryl and Cytostatics with Different Mechanisms of Action
Biophysics Pub Date : 2020-03-01 , DOI: 10.1134/s0006350920020177
L. A. Ostrovskaya , D. B. Korman , N. V. Bluhterova , M. M. Fomina , V. A. Rikova , K. A. Abzaeva

Abstract —We have compared the antitumor activity of aurumacryl, a new cancer drug, and several well-known cytostatics with different mechanisms of action, that is, cisplatin, cyclophosphan, 5-fluorouracil, and doxorubicin, on experimental murine solid tumor models: Lewis lung carcinoma and Acatol adenocarcinoma. Aurumacryl is more active than the listed cytostatics except for cyclophosphan. Aurumacryl inhibits the growth of Lewis lung carcinoma and Acatol adenocarcinoma by 70 and 74%, respectively, compared to the control.

中文翻译:

Aurumacryl和不同作用机制的细胞抑制剂的抗肿瘤活性的实验比较

摘要 —我们在实验性小鼠实体瘤模型中比较了 aurumacryl(一种新的抗癌药物)和几种具有不同作用机制的知名细胞抑制剂(即顺铂、环磷酰胺、5-氟尿嘧啶和多柔比星)的抗肿瘤活性:Lewis肺癌和阿卡托尔腺癌。除了环磷酰胺外,Aurumacryl 比所列的细胞抑制剂更具活性。与对照相比,Aurumacryl 分别抑制 Lewis 肺癌和 Acatol 腺癌的生长 70% 和 74%。
更新日期:2020-03-01
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