Abstract —Ozone-photodynamic effects on tumor growth rate and oxidative modification of proteins in rat tissues were studied using a model of PA kidney carcinoma. It was shown that the developed experimental therapeutic method based on the joint parenteral intraperitoneal administration of an ozonated saline solution with a concentration of ozone in the ozone–oxygen mixture of 400 μg/L and a 0.3% solution of the Photosens photosensitizer intratumorally with the local action of light with a wavelength of 660 ± 10 nm for 10 min reduced the intensity of tumor growth. Normalization of the prooxidant/antioxidant balance in experimental animals was observed upon combined use of ozonated saline solution and photodynamic therapy.

中文翻译：

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臭氧光动力处理下肿瘤生长大鼠组织中蛋白质的氧化修饰

摘要——使用 PA 肾癌模型研究了臭氧光动力对大鼠组织中肿瘤生长速率和蛋白质氧化修饰的影响。结果表明，开发的实验治疗方法基于联合胃肠外注射臭氧浓度为 400 μg/L 的臭氧盐水溶液和 0​​.3% 的 Photosens 光敏剂溶液与局部肿瘤内注射。波长为 660 ± 10 nm 的光作用 10 分钟可降低肿瘤生长的强度。在联合使用臭氧盐水溶液和光动力疗法后，观察到实验动物中促氧化/抗氧化平衡的正常化。