Abstract

A series of new methyl (2Z)-4-aryl-2-{4-[(4,6-dimethylpyrimidin-2-yl)-sulfamoyl]phenylamino}-4-oxobut-2-enoates was synthesized by the reaction of methyl esters of aroylpyruvic acids with 2-(4-aminobenzenesulfamido)-4,6-dimethylpyrimidine in a mixture of acetic acid–ethanol (1 : 1). The obtained 4-oxobut-2-enoates reacted with silver nitrate in ethanol–DMF (2 : 1) to form their silver salts. The antimicrobial activity of the compounds was studied.

中文翻译：

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（2 Z）-4-芳基-2- {4-[（4,6-二甲基嘧啶-2-基）氨磺酰基]苯氨基} -4-氧代丁-2-烯酸酯及其银盐的合成及抑菌活性

摘要

通过一系列的反应合成了一系列新的（2 Z）-4-芳基-2- {4-[（（4,6-二甲基嘧啶-2-基）-氨磺酰基]苯基氨基} -4-氧代丁-2-烯酸酯。在乙酸-乙醇（1：1）的混合物中，芳酰基丙酮酸与2-（4-氨基苯磺酰胺基）-4,6-二甲基嘧啶的甲基酯。得到的4-氧代丁-2-烯酸酯与硝酸银在乙醇-DMF（2：1）中反应形成其银盐。研究了这些化合物的抗菌活性。