Cardiovascular disease (CVD) is a worldwide health problem with growing up rates of mortality and morbidity. Many risk factors, including high blood pressure, cigarette smoking, diabetes, obesity, and dyslipidemia are responsible for CVD. CVD can be prevented by some simple and cost-effective steps such as smoking cessation, normalizing body weight, regular physical activity, and dietary changes, including decreasing saturated fats, increasing the intake of vegetables and fruits, and reducing sugar intake. In the last decades, growing up number of studies were performed to explain the possible function of non-nutrient substances from the diet which might prevent CVD. One of these natural compounds is quercetin which is widely present in vegetables, tea, fruits and wine. Many in vitro, in vivo and clinical studies have indicated the cardioprotective functions of quercetin. They can be explained by quercetin’s reducing blood pressure, antioxidant potential and some other activities. This review evaluates the experimental and clinical studies that have studied the effect of quercetin in CVD and summarizes the molecular mechanisms of action as well as clinical effects of quercetin in CVD.

中文翻译：

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槲皮素作为心血管疾病预防和治疗的天然解决方案的分子和生物学功能

心血管疾病 (CVD) 是一个全球性的健康问题，死亡率和发病率不断上升。许多危险因素，包括高血压、吸烟、糖尿病、肥胖和血脂异常，都是 CVD 的原因。可以通过一些简单且具有成本效益的步骤来预防 CVD，例如戒烟、使体重正常化、定期体育活动和饮食改变，包括减少饱和脂肪、增加蔬菜和水果的摄入量以及减少糖的摄入量。在过去的几十年里，越来越多的研究被用来解释饮食中非营养物质可能预防心血管疾病的可能功能。其中一种天然化合物是槲皮素，广泛存在于蔬菜、茶、水果和葡萄酒中。许多体外，体内和临床研究表明槲皮素具有心脏保护功能。它们可以通过槲皮素降低血压、抗氧化潜力和其他一些活性来解释。本综述评估了研究槲皮素在 CVD 中的作用的实验和临床研究，并总结了槲皮素在 CVD 中的分子作用机制和临床作用。