Phosphate sugar isomerases, catalyzing the isomerization between ketopentose/ketohexose phosphate and aldopentose/aldohexose phosphate, play an important role in microbial sugar metabolism. They are present in a wide range of microorganisms. They have attracted increasing research interest because of their broad substrate specificity and great potential in the enzymatic production of various rare sugars. Here, the enzymatic properties of various phosphate sugar isomerases are reviewed in terms of their substrate specificities and their applications in the production of valuable rare sugars because of their functions such as low-calorie sweeteners, bulking agents, and pharmaceutical precursor. Specifically, we focused on the industrial applications of D-ribose-5-phosphate isomerase and D-mannose-6-phosphate isomerase to produce D-allose and L-ribose, respectively.

中文翻译：

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磷酸糖异构酶及其在稀有糖生物转化中的潜力。

磷酸糖异构酶，催化酮戊糖/酮己糖磷酸和醛戊糖/醛糖己糖磷酸之间的异构化，在微生物糖代谢中起重要作用。它们存在于各种各样的微生物中。由于它们广泛的底物特异性和酶促生产各种稀有糖的巨大潜力，它们吸引了越来越多的研究兴趣。在这里，由于其低热量甜味剂，填充剂和药物前体的功能，因此根据其底物特异性及其在有价值的稀有糖的生产中的应用对各种磷酸糖异构酶的酶学性质进行了综述。具体来说，我们专注于D-核糖-5-磷酸异构酶和D的工业应用-甘露糖-6-磷酸异构酶分别产生D-阿洛糖和L-核糖。