The rapid synthesis of an amide hydrogen bond templated [1]rotaxane is reported – demonstrating a potential pathway to synthetic analogues of lasso peptides. The structures of the [1]rotaxane and its unthreaded isomer have been characterized by NMR spectroscopy and modelled using DFT calculations.

中文翻译：

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展示肽基序的酰胺氢键模板化 [1] 轮烷 - 展示了合成套索肽模拟物的便捷途径。

据报道，以酰胺氢键为模板的 [1] 轮烷的快速合成证明了合成套索肽类似物的潜在途径。[1] 轮烷及其无螺纹异构体的结构已通过 NMR 光谱表征并使用 DFT 计算建模。