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Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naïve first-episode major depressive disorder.
BMC Psychiatry ( IF 4.4 ) Pub Date : 2020-06-24 , DOI: 10.1186/s12888-020-02738-2
Md Rabiul Islam 1, 2 , Samia Ali 2 , James Regun Karmoker 2 , Mohammad Fahim Kadir 2 , Maizbha Uddin Ahmed 1 , Zabun Nahar 2 , Sardar Mohammad Ashraful Islam 2 , Mohammad Safiqul Islam 3 , Abul Hasnat 1 , Md Saiful Islam 1
Affiliation  

The alterations of biological markers are thought to be effective tools to understand the pathophysiology and management of major depressive disorder (MDD). A lot of researches has implied many markers for depression, but any of them fully discovered the association between the markers and depression. The present study investigated the serum levels of amino acids and non-enzymatic antioxidants in major depression, and also explained their association with depression. This study examined 247 MDD patients and 248 healthy controls (HCs) matched by age and sex. The Hamilton Depression Rating Scale (Ham-D) was used to all the participants to measure the severity of depression. Quantification of serum amino acids, vitamin A and E were carried out using the HPLC system whereas vitamin C levels were measured by UV-spectrophotometer. All the statistical analysis was performed by SPSS statistical software (version 23.0). The independent sample t-test, the Mann-Whitney U test, and the Fisher’s exact test were applied to detect the group differences where a Bonferroni correction applied to the p value. It was observed that serum levels of four amino acids (methionine, phenylalanine, tryptophan, and tyrosine) along with three non-enzymatic antioxidants (vitamin A, E, and C) were significantly dropped in MDD patients compared to HCs (Cohen’s d (d): − 0.45, − 0.50, − 0.68, − 0.21, − 0.27, − 0.65, and − 0.24, respectively). Furthermore, Ham-D scores of cases were negatively correlated with serum levels of methionine (r = − 0.155, p = 0.015) and tyrosine (r = − 0.172, p = 0.007). The present study suggests that lowered serum methionine, phenylalanine, tryptophan, tyrosine, and non-enzymatic antioxidants are associated with depression. The reduction of these parameters in MDD patients may be the consequence, and not the cause, of major depression.

中文翻译:

评估未经药物治疗的首发重大抑郁症患者的血清氨基酸和非酶抗氧化剂。

生物学标记的改变被认为是了解重度抑郁症(MDD)的病理生理和管理的有效工具。许多研究隐含了许多抑郁症的标志物,但是任何一项研究都充分发现了标志物与抑郁症之间的联系。本研究调查了重度抑郁症患者的血清氨基酸和非酶类抗氧化剂水平,并解释了它们与抑郁症的关系。这项研究根据年龄和性别检查了247名MDD患者和248名健康对照(HCs)。汉密尔顿抑郁量表(Ham-D)用于所有参与者以测量抑郁的严重程度。使用HPLC系统对血清氨基酸,维生素A和E进行定量,而维生素C水平通过紫外分光光度计测量。所有统计分析均通过SPSS统计软件(版本23.0)进行。采用独立样本t检验,Mann-Whitney U检验和Fisher精确检验来检测将Bonferroni校正应用于p值的组差异。据观察,与HCs相比,MDD患者的血清中四种氨基酸(蛋氨酸,苯丙氨酸,色氨酸和酪氨酸)以及三种非酶抗氧化剂(维生素A,E和C)的血清水平显着下降(Cohen d(d ):-0.45,-0.50,-0.68,-0.21,-0.27,-0.65和-0.24)。此外,病例的Ham-D评分与蛋氨酸(r = − 0.155,p = 0.015)和酪氨酸(r = − 0.172,p = 0.007)的血清水平呈负相关。本研究表明,降低了血清蛋氨酸,苯丙氨酸,色氨酸,酪氨酸,非酶类抗氧化剂与抑郁症有关。MDD患者中这些参数的降低可能是严重抑郁的结果,而不是原因。
更新日期:2020-06-24
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