Sleep disorders are a risk factor for developing a variety of mental disorders, have a negative impact on their remission rates and increase the risk of relapse. Early identification and treatment of sleep disorders is therefore of paramount importance. Unfortunately, in mental health care sleep disorders are often poorly recognized and specific treatment frequently occurs late or not at all. This protocol-paper presents a randomized controlled trial investigating the clinical relevance of early detection and treatment of sleep disorders in mental health care. The two aims of this project are 1) to determine the prevalence of sleep disorders in different mental disorders, and 2) to investigate the contribution of early identification and adequate treatment of sleep disorders in individuals with mental disorders to their sleep, mental disorder symptoms, general functioning, and quality of life. Patients newly referred to a Dutch mental health institute for psychiatric treatment will be screened for sleep disorders with the self-assessment Holland Sleep Disorders Questionnaire (HSDQ). Patients scoring above the cut-off criteria will be invited for additional diagnostic evaluation and, treatment of the respective sleep disorder. Participants will be randomly assigned to two groups: Immediate sleep diagnostics and intervention (TAU+SI-T0), or delayed start of sleep intervention (TAU+SI-T1; 6 months after inclusion). The effect of sleep treatment as add-on to treatment as usual (TAU) will be tested with regard to sleep disorder symptoms, general functioning, and quality of life (in collaboration with a psychiatric sleep centre). This trial will examine the prevalence of different sleep disorders in a broad range of mental disorders, providing information on the co-occurrence of specific sleep and mental disorders. Further, this study is the first to investigate the impact of early treatment of sleep disorders on the outcome of many mental disorders. Moreover, standard sleep interventions will be tailored to specific mental disorders, to increase their efficacy. The results of this trial may contribute considerably to the improvement of mental health care. This clinical trial has been retrospectively registered in the Netherlands Trial Register (NL8389; https://www.trialregister.nl/trial/8389) on February 2th, 2020.

中文翻译：

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精神卫生保健中早期识别和治疗睡眠障碍的临床意义：一项随机对照试验的方案。

睡眠障碍是发展各种精神障碍的危险因素，对其缓解率有负面影响，并增加了复发的风险。因此，尽早发现和治疗睡眠障碍至关重要。不幸的是，在精神卫生保健中，睡眠障碍常常被人们认识得不多，并且特定的治疗经常迟到或根本没有发生。该协议文件提出了一项随机对照试验，研究精神卫生保健中早期发现和治疗睡眠障碍的临床意义。该项目的两个目标是：1）确定不同精神障碍中的睡眠障碍患病率，以及2）研究早期识别和适当治疗精神障碍患者的睡眠障碍对他们的睡眠的贡献，精神障碍的症状，总体功能和生活质量。新近转诊到荷兰精神卫生研究所接受精神病治疗的患者将通过自我评估《荷兰睡眠障碍问卷》（HSDQ）筛查是否患有睡眠障碍。得分高于临界标准的患者将被邀请进行其他诊断评估和相应睡眠障碍的治疗。参加者将随机分为两组：立即进行睡眠诊断和干预（TAU + SI-T0），或延迟开始睡眠干预（TAU + SI-T1；入院后6个月）。将就睡眠障碍症状，总体功能和生活质量（与精神病学睡眠中心合作）测试睡眠治疗作为常规治疗（TAU）的附加手段的效果。该试验将检查广泛的精神障碍中不同睡眠障碍的患病率，并提供有关特定睡眠和精神障碍并发的信息。此外，该研究是第一个研究早期治疗睡眠障碍对许多精神障碍预后的影响的研究。此外，标准的睡眠干预措施将针对特定的精神障碍量身定制，以提高其疗效。该试验的结果可能会极大地改善精神卫生保健。该临床试验已于2020年2月2日在荷兰试验注册（NL8389; https://www.trialregister.nl/trial/8389）中进行回顾性注册。这项研究是第一个研究早期治疗睡眠障碍对许多精神障碍预后的影响的研究。此外，标准的睡眠干预措施将针对特定的精神障碍量身定制，以提高其疗效。该试验的结果可能会极大地改善精神卫生保健。该临床试验已于2020年2月2日在荷兰试验注册（NL8389; https://www.trialregister.nl/trial/8389）中进行回顾性注册。这项研究是第一个研究早期治疗睡眠障碍对许多精神障碍预后的影响的研究。此外，标准的睡眠干预措施将针对特定的精神障碍量身定制，以提高其疗效。该试验的结果可能会极大地改善精神卫生保健。该临床试验已于2020年2月2日在荷兰试验注册（NL8389; https://www.trialregister.nl/trial/8389）中进行回顾性注册。