(S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile ((S)-CIK) is a key intermediate to (S)-clopidogrel which is one of the most salable worldwide antiplatelet and antithrombotic drugs. We show herein a facile meth-od for direct synthesis of (S)-CIK via one-pot in situ Strecker reaction using homochiral covalent framework catalyst in a het-erogeneous way. The asymmetric synthesis herein involves a photothermal conversion triggered thermally-driven reaction which affords (S)-CIK in 98% yield with 94% enantiomeric excess under visible-light irradiation. Furthermore, the above approach is readily extended to a gram-scale production on a fixed-bed continuous-flow model reactor. The potential utility of this strategy is highlighted by the preparation of many more other types of chiral drugs and drug intermediates in a green and facile way.

中文翻译：

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用于催化不对称合成药物中间体的同手性共价有机骨架

(S)-2-(2-氯苯基)-2-(6,7-二氢噻吩并[3,2-c]吡啶-5(4H)-基)乙腈((S)-CIK)是( S)-氯吡格雷，它是全球最畅销的抗血小板和抗血栓药物之一。我们在此展示了一种使用同手性共价骨架催化剂以异相方式通过一锅原位 Strecker 反应直接合成 (S)-CIK 的简便方法。本文的不对称合成涉及光热转化引发的热驱动反应，其在可见光照射下以 98% 的产率提供 (S)-CIK，对映体过量为 94%。此外，上述方法很容易扩展到固定床连续流动模型反应器上的克级生产。