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Progress with stem cell therapies for tendon tissue regeneration.
Expert Opinion on Biological Therapy ( IF 4.6 ) Pub Date : 2020-06-29 , DOI: 10.1080/14712598.2020.1786532
Filippo Migliorini 1 , Markus Tingart 1 , Nicola Maffulli 2, 3, 4
Affiliation  

ABSTRACT

Introduction

Chronic musculoskeletal pain is very prevalent, and accounts for major health-care expenses. Many of the present therapeutic modalities are only partially effective, and great interest is now posed on regenerative medicine.

Areas covered

The authors discuss the role of a variety of regenerative medicine options to induce and favor regeneration and healing of tendon tissue, focusing on the role of mesenchymal stem cell therapy and their derivatives.

Expert opinion

Stem cells, tissue engineering, and growth factors are new strategies for tendon repair and regeneration. MSCs not only can differentiate in tendon cells, but also secrete several cytokines that modulate inflammation and tissue healing. Future studies should be undertaken to overcome current obstacles to clinical translation. Further investigation of cell source, isolation, expansion, and differentiation methods, characterization of the tenogenic differentiation pathways, and clarifications of tendon-specific molecular markers are required. The role of donor variability, tendon type, and anatomic location also requires further understanding and research.



中文翻译:

用于肌腱组织再生的干细胞疗法的进展。

摘要

介绍

慢性肌肉骨骼疼痛非常普遍,占主要的医疗保健费用。当前的许多治疗方式仅部分有效,并且现在人们对再生医学产生了极大的兴趣。

覆盖区域

作者讨论了各种再生医学选择在诱导和促进肌腱组织再生和愈合中的作用,重点是间充质干细胞疗法及其衍生物的作用。

专家意见

干细胞,组织工程和生长因子是肌腱修复和再生的新策略。MSC不仅可以在肌腱细胞中分化,还可以分泌几种调节炎症和组织愈合的细胞因子。应该进行进一步的研究以克服当前临床翻译的障碍。需要对细胞来源,分离,扩增和分化方法进行进一步研究,对肌腱分化途径进行表征,并阐明肌腱特异性分子标记。供体变异性,肌腱类型和解剖位置的作用也需要进一步的理解和研究。

更新日期:2020-06-29
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