A novel nanostructured lipid carrier (NLC) loaded with Antarctic krill oil while using 1,3‐glycerol distearate (GDS) as the solid lipid was prepared through ultrasonication. The NLCs were optimised for ingredient formulation by single‐factor experiment on the basis of their effects on the particle size and polydispersity index (PDI) of the NLCs. 2% (w/w) lecithin and 10% lipid phase of which krill oil accounted for 50% (w/w) were applied to develop the optimised NLC dispersion. The particle size, PDI and zeta potential of this NLC were 112 nm, 0.270 and −30.8 mV, respectively, indicating good dispersion uniformity and stability. Transmission electron microscopy (TEM) revealed that the optimised NLC particles were spherical and uniformly dispersed without apparent aggregation. Differential calorimetry scanning (DSC) and X‐ray diffraction (XRD) showed that the optimised NLC had less‐ordered crystalline structure contributing to the high entrapment efficiency (> 99%) of EPA and DHA.

中文翻译：

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基于1,3-甘油二硬脂酸酯的新型磷虾油纳米结构脂质载体的开发与表征

通过超声处理，制备了一种新型的纳米结构脂质载体（NLC），其中载有南极磷虾油，同时使用1,3-甘油二硬脂酸酯（GDS）作为固体脂质。基于单因素实验对NLC的粒径和多分散指数（PDI）的影响，对NLC的成分配方进行了优化。应用2％（w / w）卵磷脂和10％脂质相（磷虾油占50％（w / w））来开发优化的NLC分散体。该NLC的粒径，PDI和ζ电位分别为112nm，0.270和-30.8mV，表明良好的分散均匀性和稳定性。透射电子显微镜（TEM）显示，优化的NLC颗粒为球形，均匀分散，没有明显的聚集。