4‐Hydroxyphenylpyruvate dioxygenase (HPPD) plays an important role in addressing the issue of plant protection research. In a continuing effort to discover novel HPPD inhibitors, we adopted a bioisosterism strategy to design a series of novel arylthioacetic acid scaffold based on the previously discovered aryloxyacetic acid scaffold. This study sheds new light on the discovery of novel HPPD inhibitors.

中文翻译：

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发现了新的芳基硫代乙酸衍生物作为4-羟基苯基丙酮酸双加氧酶抑制剂。

4-羟基苯丙酮酸双加氧酶（HPPD）在解决植物保护研究方面起着重要作用。为了不断发现新型HPPD抑制剂，我们采用了一种生物立体异构策略，在先前发现的芳氧基乙酸支架的基础上，设计了一系列新型芳硫基乙酸支架。这项研究为新型HPPD抑制剂的发现提供了新的思路。