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Individuals with IgE antibodies to α‐Gal and CCD show specific IgG subclass responses different from subjects non‐sensitized to oligosaccharides
Clinical & Experimental Allergy ( IF 6.1 ) Pub Date : 2020-07-14 , DOI: 10.1111/cea.13695
Patricia Román-Carrasco 1 , Wolfgang Hemmer 2 , Christoph Klug 1 , Anja Friedrich 1 , Peter Stoll 1 , Margarete Focke-Tejkl 3 , Friedrich Altmann 4 , Santiago Quirce 5 , Ines Swoboda 1
Affiliation  

Two kinds of IgE antibody responses against protein-linked carbohydrates are known: IgE responses against cross-reactive carbohydrate determinants (CCDs) present in plants and insect venoms and IgE responses against galactose-containing determinants occurring in all non-primate mammals and in New World monkeys1 . Both oligosaccharides are N-glycans, asparagine-linked carbohydrate moieties. The major CCD epitope has been defined as core α-1,3-linked fucose and the galactose-containing epitope as galactose-α-1,3-galactose (α-Gal).

中文翻译:

具有针对 α-Gal 和 CCD 的 IgE 抗体的个体表现出与对寡糖不敏感的受试者不同的特异性 IgG 亚类反应

已知有两种针对蛋白质连接碳水化合物的 IgE 抗体反应:针对存在于植物和昆虫毒液中的交叉反应性碳水化合物决定簇 (CCD) 的 IgE 反应和针对所有非灵长类哺乳动物和新世界中发生的含半乳糖决定簇的 IgE 反应猴子1。两种寡糖都是 N-聚糖,天冬酰胺连接的碳水化合物部分。主要的 CCD 表位被定义为核心 α-1,3-连接的岩藻糖,含半乳糖的表位被定义为半乳糖-α-1,3-半乳糖 (α-Gal)。
更新日期:2020-07-14
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