In article number 1903366, Fudi Wang, Junxia Min, Liwei Xie, and co‐workers demonstrate the essential role of transferrin receptor 1 (Tfr1) in the thermogenic capacity and cell fate of brown/beige adipocytes. Under cold exposure, Tfr1 expression is transcriptionally regulated by hypoxia‐inducible factor 1α (HIF1α) in beige adipocytes. Targeting Tfr1 serves as a potential strategy for preventing and treating metabolic diseases.

中文翻译：

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生热：转铁蛋白受体1调节棕色/米色脂肪细胞的产热能力和细胞命运（Adv。Sci。12/2020）

在文章1903366中，王付迪，闵俊霞，谢立伟及其同事证明了转铁蛋白受体1（Tfr1）在棕色/米色脂肪细胞的产热能力和细胞命运中的重要作用。在冷暴露下，米色脂肪细胞中的Tfr1表达受缺氧诱导因子1α（HIF1α）的转录调控。靶向Tfr1作为预防和治疗代谢性疾病的潜在策略。