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Dosimetric characterization of an X-ray irradiator for use with cells
Radiation Physics and Chemistry ( IF 2.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.radphyschem.2020.109065
Shalaine S. Tatu , Bernard Isaiah D. Lo , Judiel John M. Cortez , Merry Jaine T. Ortillo , Gio Ferson M. Bautista , Mary Joy V. Erojo , Chitho P. Feliciano

Abstract Purpose This study aims to characterize an X-ray irradiator (CellRad™, Precision X-ray Inc., North Branford, CT) for use with cells using its internal parallel-plate ionization chamber by evaluating the linearity and repeatability of dose and dose rates delivered by the machine. Methodology Using the on-board software modules for X-ray irradiation, dose linearity and repeatability tests were performed at the following setting: 130 kVp, 5.0 mA, and 33.0 cm source-to-shelf distance. Four (4) setups with distinct combinations of 0.5-mm Al added filtration and turntable rotation settings were employed. The measurements obtained from the internal ionization chamber were analyzed using statistical tests. Results The X-ray irradiator can generate temporally linear and repeatable doses from aluminum-filtered (0.5 mm) and unfiltered X-ray beams (130 kV, 5.0 mA). At a 33.0-cm source-to-shelf distance, the computed dose rates indicate that the X-ray irradiator can deliver 1.345 ± 0.046 Gy/min and 6.718 ± 0.11 Gy/min at the specified tube and shelf settings, with and without the 0.5 mm Al added filter, respectively. An acceptable level of repeatability of the dose is achieved after at least 20 s of irradiation time. The automatic dose control function of the irradiator was also found to measure accumulated doses within ± 5% of the target dose for all the setups employed in this study. The results also revealed that turntable rotation has no significant effect on the dose measured by the internal dosimeter for both filtered and unfiltered beams. On the other hand, adding a 0.5-mm Al filtration significantly alters the beam by decreasing the measured dose rate to only 20% of that of the unfiltered beam. Conclusions and recommendations This study demonstrates that the X-ray irradiator can generate and measure precise radiation doses that vary linearly with irradiation time. The available irradiation modules in the on-board software can be used to deliver doses within ± 5% of the target dose, although irradiation time should be at least 20 s to achieve acceptable dose repeatability. Further dosimetric calibration and output verification using external dosimetry system(s) should be conducted for the complete dosimetric characterization of this X-ray irradiator.

中文翻译:

用于细胞的 X 射线辐照器的剂量学表征

摘要 目的本研究旨在通过评估剂量和剂量的线性和可重复性来表征 X 射线辐照器(CellRad™,Precision X-ray Inc.,North Branford,CT)使用其内部平行板电离室与细胞一起使用。机器提供的费率。方法论 使用用于 X 射线照射的机载软件模块,在以下设置下执行剂量线性和可重复性测试:130 kVp、5.0 mA 和 33.0 cm 源到架距离。采用了四 (4) 个具有 0.5 毫米铝添加过滤和转盘旋转设置的不同组合的设置。使用统计测试分析从内部电离室获得的测量结果。结果 X 射线辐照器可以从铝过滤 (0. 5 毫米)和未过滤的 X 射线束(130 kV,5.0 mA)。在 33.0 厘米的源到架子距离处,计算出的剂量率表明 X 射线辐照器在指定的管子和架子设置下可以提供 1.345 ± 0.046 Gy/min 和 6.718 ± 0.11 Gy/min,无论有没有分别添加了 0.5 mm 铝过滤器。在至少 20 秒的辐照时间后达到可接受的剂量重复性水平。还发现辐照器的自动剂量控制功能可以测量本研究中使用的所有设置的目标剂量 ± 5% 内的累积剂量。结果还表明,转盘旋转对内部剂量计测量的过滤和未过滤光束的剂量没有显着影响。另一方面,添加一个 0。5 毫米铝过滤通过将测量的剂量率降低到未过滤光束的 20%,从而显着改变光束。结论和建议 本研究表明,X 射线辐照器可以产生和测量随辐照时间线性变化的精确辐射剂量。机载软件中的可用辐照模块可用于在目标剂量的 ± 5% 内提供剂量,但辐照时间应至少为 20 秒以实现可接受的剂量重复性。应使用外部剂量测定系统进行进一步的剂量测定校准和输出验证,以对该 X 射线辐照器进行完整的剂量测定表征。结论和建议 本研究表明,X 射线辐照器可以产生和测量随辐照时间线性变化的精确辐射剂量。机载软件中的可用辐照模块可用于在目标剂量的 ± 5% 内提供剂量,但辐照时间应至少为 20 秒以实现可接受的剂量重复性。应使用外部剂量测定系统进行进一步的剂量测定校准和输出验证,以对该 X 射线辐照器进行完整的剂量测定表征。结论和建议 本研究表明,X 射线辐照器可以产生和测量随辐照时间线性变化的精确辐射剂量。机载软件中的可用辐照模块可用于在目标剂量的 ± 5% 内提供剂量,但辐照时间应至少为 20 秒以实现可接受的剂量重复性。应使用外部剂量测定系统进行进一步的剂量测定校准和输出验证,以对该 X 射线辐照器进行完整的剂量测定表征。
更新日期:2020-11-01
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