Abstract Intravascular optical coherence tomography (IVOCT) has been widely used in clinical coronary artery intervention field. Owing to defocus and contrast agent absorption effects, the intensity fluctuation caused by imaging catheter locating at an eccentric position significantly influence the quality of IVOCT imaging and even plaque type identification. In this paper, we present a novel method to compensate intensity fluctuation caused by defocus and contrast agent absorption in IVOCT imaging. We construct a principle model of IVOCT intensity signal based on defocus function and contrast agent absorption. By measuring the parameters of defocus function and contrast agent absorption, we compensate intensity fluctuation of each A-line caused by defocus and contrast agent absorption effects in IVOCT imaging. In clinical imaging, the proposed method improve the quality of IVOCT images and is helpful for plaque type identification. The average signal to noise ratio (SNR) of 200 images after compensation increase 6.5 dB than that before compensation.

中文翻译：

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血管内光学相干断层扫描成像中的散焦和造影剂吸收补偿方法

摘要 血管内光学相干断层扫描（IVOCT）已广泛应用于临床冠状动脉介入领域。由于散焦和造影剂吸收效应，成像导管位于偏心位置引起的强度波动显着影响IVOCT成像质量甚至斑块类型识别。在本文中，我们提出了一种新方法来补偿 IVOCT 成像中由散焦和造影剂吸收引起的强度波动。我们构建了基于散焦函数和造影剂吸收的 IVOCT 强度信号的原理模型。通过测量散焦函数和造影剂吸收的参数，我们补偿了IVOCT成像中由散焦和造影剂吸收效应引起的每条A线的强度波动。在临床影像学中，所提出的方法提高了 IVOCT 图像的质量，有助于斑块类型识别。补偿后200幅图像的平均信噪比（SNR）比补偿前提高了6.5 dB。