Nonbacterial prostatitis has been reported to be associated with reduced zinc intake, but the role of zinc remains unclear. Here, oyster hydrolysate-zinc complex (OH-Zn) was prepared to attenuate rat prostatitis. We found using dynamic light scattering and energy-dispersive X-ray analysis that OH-Zn was a nanostructure complex (49.06 ± 0.26 nm) with a prominent signal of zinc. Fourier transform infrared spectroscopy illustrated that OH-Zn was formed via interactions among zinc ions, amino nitrogen atoms and carboxyl oxygen. OH-Zn treatment significantly reduced the prostatic index value, prostatic specific antigen, tumor necrosis factor-alpha, interleukin-1 beta, malonaldehyde, prostatic acid phosphatase, and acid phosphatase in prostatitis rats. OH-Zn increased the levels of superoxide dismutase, glutathione and serum zinc concentration in prostatitis rats relative to the control group. Moreover, histological analyses revealed OH-Zn prevented the carrageen-induced pathological morphology of the prostate. Therefore, OH-Zn might be a preferable paradigm to ameliorate prostatitis as a novel zinc supplement.

据报道，非细菌性前列腺炎与锌的摄入减少有关，但锌的作用仍不清楚。在这里，准备牡蛎水解物-锌复合物（OH-Zn）来减轻大鼠前列腺炎。我们使用动态光散射和能量色散X射线分析发现，OH-Zn是一种纳米结构复合物（49.06±0.26 nm），具有明显的锌信号。傅立叶变换红外光谱表明，OH-Zn是通过锌离子，氨基氮原子和羧基氧之间的相互作用形成的。OH-Zn处理可显着降低前列腺炎大鼠的前列腺指数值，前列腺特异性抗原，肿瘤坏死因子-α，白介素-1β，丙二醛，前列腺酸性磷酸酶和酸性磷酸酶。OH-Zn增加了超氧化物歧化酶的水平，前列腺炎大鼠的谷胱甘肽和血清锌浓度相对于对照组。而且，组织学分析显示OH-Zn阻止了角叉菜胶引起的前列腺病理形态。因此，OH-Zn作为一种新型的锌补充剂可能是缓解前列腺炎的理想范例。