The use of Plant Food Supplements (PFS) has increased significantly in the last decades. The wide diffusion of these products has raised concerns about their safety and to solve at least some critical points the EU Project PlantLIBRA was financed. The project included among its goals the collection of adverse effects due to PFS; using different sources: 1) the scientific literature; 2) European Poison Centers; 3) the PlantLIBRA consumer survey. New data from the Pavia Poison Centre, ANSES and FDA were elaborated after the end of EU Project. Adverse effects were analysed according to the WHO causal relationship criteria. Valeriana officinalis and Camellia sinensis were the plants most frequently involved in adverse effects in European countries. Although mild/moderate symptomatology were generally described, some severe outcomes occurred, including fatal cases. Nervous and gastrointestinal systems were the main targets; the intestinal disorders were associated with fibres and polyphenols present in some plants.

在过去的几十年中，植物食品补充剂（PFS）的使用已大大增加。这些产品的广泛使用引起了人们对其安全性的担忧，并至少解决了一些由EU Project PlantLIBRA资助的关键问题。该项目的目标包括收集由于PFS造成的不利影响；使用不同的来源：1）科学文献；2）欧洲毒物中心；3）PlantLIBRA消费者调查。欧盟项目结束后，详细说明了帕维亚毒物中心，ANSES和FDA的新数据。根据世界卫生组织因果关系标准分析不良反应。缬草和山茶是欧洲国家中最经常出现不良影响的植物。尽管一般描述了轻度/中度症状，但仍发生了一些严重的后果，包括致命的病例。神经和胃肠系统是主要目标。肠道疾病与某些植物中存在的纤维和多酚有关。