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Fisetin prevents the aging-associated decline in relative spectral power of α, β and linked MUA in the cortex and behavioral alterations.
Experimental Gerontology ( IF 3.9 ) Pub Date : 2020-06-24 , DOI: 10.1016/j.exger.2020.111006
Jharana Das 1 , Rameshwar Singh 1 , Stanzin Ladol 2 , Sasmita Kumari Nayak 3 , Deepak Sharma 1
Affiliation  

Mental health in old age is of great concern due to the increased incidence of neurological and psychiatric diseases. With age, probability of cognitive and behavioral deficits increase and the prognosis deteriorates. Although a few in vitro studies have reported that flavonoid fisetin is beneficial for healthy aging, its effect on deteriorating mental health with aging in vivo is very limited and poorly understood. The brain aging is physiologically characterized by electroencephalograph (EEG) wave frequency, power, and distribution. Brain oscillatory waves from neural tissue get altered by various sensory-cognitive inputs. Besides, the fast-wave α(8–12 Hz)- and β(12–28 Hz)-oscillations are associated with coordination and indeed deal with complex behavioral performances. Therefore, the effect of fisetin supplementation on age-associated EEG mean cortical spectral power in α- and β-oscillations, multi-unit activity (MUA) count were studied in vivo which was not addressed so far. Besides, age-associated cognitive and behavioral alterations were also studied.

The relative spectral power of α and β declined along with the MUA count in aged rats compared to young. However, supplementing fisetin for four weeks has improved relative α-power, β-power, and MUA count in aged rats. Also, fisetin supplemented aged rats showed significantly improved cognitive and behavioral performances than aged controls.

These findings demonstrated the relative cortical spectral power in α-, β-oscillations, and MUA count change in aged rats and that some of these changes and behavioral alterations may be partly as a result of oxidative stress, which was prevented significantly in fisetin supplemented aged rats. Thus, fisetin boosted mental health in the aged animals.



中文翻译:

Fisetin防止了与衰老相关的皮层和行为改变中α,β和连锁MUA的相对光谱功率下降。

由于神经系统疾病和精神疾病的发病率增加,老年人的心理健康受到极大关注。随着年龄的增长,认知和行为缺陷的可能性增加,并且预后恶化。尽管一些体外研究报道了类黄酮非瑟酮有益于健康的衰老,但其对体内衰老导致的心理健康恶化的作用非常有限,人们对此知之甚少。脑老化的生理特征是脑电图(EEG)的频率,功率和分布。来自神经组织的大脑振荡波会因各种感官认知输入而改变。此外,α(8–12 Hz)和β(12–28 Hz)的快速波振荡与协调相关,并且确实处理复杂的行为表现。因此,在体内研究了非瑟酮补充剂对与年龄相关的脑电图的平均皮层频谱功率,多单位活性(MUA)计数的影响,目前尚未解决。此外,还研究了与年龄相关的认知和行为改变。

与年幼的大鼠相比,老年大鼠的α和β的相对光谱功率随MUA计数下降。然而,补充非瑟定四周可改善老年大鼠的相对α能量,β能量和MUA计数。此外,补充非瑟定的老年大鼠显示出比老年对照组明显改善的认知和行为表现。

这些发现表明,老年大鼠的α-,β-振荡和MUA计数变化具有相对皮层光谱功率,其中某些变化和行为改变可能部分是由于氧化应激所致,而在补充非瑟定的老年动物中,氧化应激得到了显着的抑制。大鼠。因此,非瑟定促进了老年动物的心理健康。

更新日期:2020-07-13
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