当前位置: X-MOL 学术Environ. Int. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Long-term exposure to ambient source-specific particulate matter and its components and incidence of cardiovascular events - The Heinz Nixdorf Recall study.
Environment International ( IF 11.8 ) Pub Date : 2020-06-24 , DOI: 10.1016/j.envint.2020.105854
Vitalijs Rodins 1 , Sarah Lucht 1 , Simone Ohlwein 1 , Frauke Hennig 1 , Vanessa Soppa 1 , Raimund Erbel 2 , Karl-Heinz Jöckel 2 , Christian Weimar 3 , Dirk M Hermann 4 , Sara Schramm 2 , Susanne Moebus 5 , Uta Slomiany 2 , Barbara Hoffmann 1
Affiliation  

Background

Few studies have examined the risk of long-term exposure to source-specific airborne pollutants on incidence of cerebrovascular and cardiovascular events.

Objectives

We aimed to estimate the effect of long-term exposure to source-specific air pollution and particulate matter (PM) components on incidence of stroke, coronary heart disease (CHD), and total cardiovascular events (CVE) in the population-based Heinz Nixdorf Recall study (HNR).

Methods

We used baseline (2000–2003) and 14-year follow-up data of the HNR Study, an ongoing population-based prospective cohort study in Western Germany. Participants’ residential mean exposures to NO2 and total and source-specific PM10, PM2.5, accumulation mode particle number concentration (PNAM), and PM components were modelled using a dispersion and chemical transport model. We used Cox regression to evaluate the effect of pollutants (per 1 μg/m3 increase and per interquartile range – IQR) on risk of stroke and CHD, adjusting for socio-demographic characteristics, lifestyle risk factors and nighttime traffic noise exposure.

Results

In 4,105 included participants (aged 45–76 at baseline, 52.5% women), we observed 118 cases of first stroke and 373 cases of first CHD during 46,748 person-years under risk. The median survival time within the cohort was 13.3 years. No effect of exposure to ambient air pollution on risk of CHD was observed, but distinct effects were observed for stroke. Ambient traffic-specific PM showed a stronger effect on stroke than industry-specific PM: hazard ratios (95% confidence interval) for total, traffic-specific, and industry-specific PM2.5 were 1.16 (1.02–1.34), 2.53 (1.07–5.97), and 1.27 (1.03–1.56) per 1 μg/m3 increase, respectively. PM components showed no substantially different effects from those of total PM per IQR, but higher associations were observed for NH4 and SO4 per 1 μg/m3. However, the exposure contrast of ammonium and sulfate components was very low.

Conclusion

Traffic-specific PM exhibited stronger effects than total and industry-specific PM on risk of stroke. Among components, NH4 and SO4 showed higher effects. No effect was observed for PM and CHD.



中文翻译:

长期暴露于特定环境源的颗粒物及其成分和心血管事件的发生率-亨氏Nixdorf召回研究。

背景

很少有研究检查过长期暴露于特定来源的空气污染物对脑血管和心血管事件的发生风险。

目标

我们旨在评估长期暴露于特定源的空气污染和颗粒物(PM)成分对基于人群的Heinz Nixdorf中风,冠心病(CHD)和总心血管事件(CVE)的发生率的影响回顾研究(HNR)。

方法

我们使用了HNR研究的基线(2000-2003年)和14年的随访数据,该研究是德国西部正在进行的基于人群的前瞻性队列研究。使用分散和化学迁移模型对参与者的住宅平均暴露于NO 2以及总和特定于源的PM 10,PM 2.5,累积模式颗粒数浓度(PN AM)和PM成分进行建模。我们使用Cox回归评估污染物(每增加1μg/ m 3和每四分位间距– IQR)对中风和冠心病风险的影响,并根据社会人口统计学特征,生活方式风险因素和夜间交通噪声暴露进行调整。

结果

在4,105名参与者(基线年龄为45-76岁,女性为52.5%)中,我们观察到46,748人年内有118例首次卒中和373例首次CHD。该队列的中位生存时间为13.3年。没有观察到暴露于环境空气污染对冠心病风险的影响,但是对于中风观察到了明显的影响。与特定行业的PM相比,特定于环境的交通PM对中风的影响更大:总的,特定于流量和特定行业的PM 2.5的危险比(95%置信区间)分别为1.16(1.02–1.34),2.53(1.07–每增加1μg/ m 3分别增加5.97)和1.27(1.03-1.56)。PM成分与IQR总PM的影响没有实质性差异,但是NH 4的缔合程度更高和SO 4每1μg/ m 3。但是,铵和硫酸盐成分的曝光对比度非常低。

结论

特定于交通的PM对中风风险的影响要强于针对特定行业的PM。在组分中,NH 4和SO 4表现出更高的作用。对于PM和CHD没有观察到影响。

更新日期:2020-06-24
down
wechat
bug