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A 3'-tRNA-derived fragment enhances cell proliferation, migration and invasion in gastric cancer by targeting FBXO47.
Archives of Biochemistry and Biophysics ( IF 3.9 ) Pub Date : 2020-06-24 , DOI: 10.1016/j.abb.2020.108467
Fei Zhang 1 , Jinxin Shi 1 , Zhonghua Wu 1 , Peng Gao 1 , Weixu Zhang 1 , Bicheng Qu 1 , Xin Wang 1 , Yongxi Song 1 , Zhenning Wang 1
Affiliation  

Increasing evidence demonstrates that tRNA-derived fragments (tRFs) exert important effects and are dysregulated in various human cancer types. However, their roles in gastric cancer (GC) remain unknown. Here we identified the functional effects of tRF-3019a (derived from tRNA-Ala-AGC-1-1) in GC. We demonstrated that tRF-3019a was upregulated in GC tissues and cell lines. Phenotypic studies revealed that tRF-3019a overexpression enhances GC cell proliferation, migration and invasion. Conversely, tRF-3019a knockdown inhibits GC cell malignant activities. Mechanistic investigation implies that tRF-3019a directly regulates tumor suppressor gene FBXO47. Furthermore, tRF-3019a levels may discriminate GC tissues from nontumorous tissues. Taken together, our results reveal that tRF-3019a modulates GC cell proliferation, migration and invasion by targeting FBXO47, and it may serve as a potential diagnostic biomarker for GC.



中文翻译:

3'-tRNA 衍生片段通过靶向 FBXO47 增强胃癌细胞增殖、迁移和侵袭。

越来越多的证据表明,tRNA 衍生片段 (tRF) 发挥重要作用,并且在各种人类癌症类型中失调。然而,它们在胃癌(GC)中的作用仍然未知。在这里,我们确定了 tRF-3019a(源自 tRNA-Ala-AGC-1-1)在 GC 中的功能影响。我们证明 tRF-3019a 在 GC 组织和细胞系中上调。表型研究表明,tRF-3019a 过表达可增强 GC 细胞增殖、迁移和侵袭。相反,tRF-3019a 敲低会抑制 GC 细胞恶性活动。机制研究表明 tRF-3019a 直接调节肿瘤抑制基因 FBXO47。此外,tRF-3019a 水平可以将 GC 组织与非肿瘤组织区分开来。总之,我们的结果表明 tRF-3019a 调节 GC 细胞增殖,

更新日期:2020-06-24
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