Purpose

To evaluate the association of objectively measured physical activity (PA) and sedentary behaviour before and during in vitro fertilization (IVF) with controlled ovarian stimulation (COS) and pregnancy outcomes.

Methods

This longitudinal study involved 107 infertile women undergoing IVF treatment. PA and sedentary behaviour were measured for 14 consecutive days using accelerometry as follows: (1) before IVF treatment, (2) during IVF at the implantation time, immediately after embryo transfer, and (3) after positive pregnancy test. Total screen time was assessed by questionnaires. COS results were measured as the number of oocytes and embryos obtained, and the study outcomes included positive hCG, clinical pregnancy, and live birth.

Results

Compared with baseline activity levels, women significantly reduced their PA and increased sedentary behaviour during IVF (p ≤ 0.001). Higher average PA, light PA, and ratio between breaks in every ≥ 30-min blocks of sedentary time showed positive associations, while sedentary time, number, and time accumulated in blocks of ≥ 30 min of sedentary time associated negatively with oocyte and embryo counts (all p < 0.05). Women with high total screen time during non-work days (≥ 7 h) obtained 4.7 oocytes (p = 0.005) and 2.8 embryos (p = 0.008) less in COS. PA and sedentary behaviour before and during IVF did not affect the positive hCG, clinical pregnancy, and live birth outcomes.

Conclusion

Our study results suggest that higher time spent in PA and lower time spent in sedentary behaviour before entering assisted reproduction is associated with better COS outcomes, while activity levels before and during IVF do not affect the implantation, pregnancy, and live birth outcomes.

中文翻译：

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体外受精治疗之前和期间的母亲体力活动和久坐行为：一项纵向研究，探索与受控卵巢刺激和妊娠结果的关联。

目的

评估在体外受精 (IVF) 之前和期间客观测量的体力活动 (PA) 和久坐行为与受控卵巢刺激 (COS) 和妊娠结局的关联。

方法

这项纵向研究涉及 107 名接受试管婴儿治疗的不孕妇女。使用加速度计连续 14 天测量 PA 和久坐行为，如下所示：（1）IVF 治疗前，（2）IVF 植入时，胚胎移植后立即，以及（3）阳性妊娠试验后。通过问卷评估总屏幕时间。COS 结果以获得的卵母细胞和胚胎的数量来衡量，研究结果包括 hCG 阳性、临床妊娠和活产。

结果

与基线活动水平相比，女性在 IVF 期间显着降低了 PA 并增加了久坐行为（p  ≤ 0.001）。较高的平均 PA、轻度 PA 和每 ≥ 30 分钟久坐时间块中的休息之间的比率显示出正相关，而久坐时间、数量和久坐时间在 ≥ 30 分钟久坐时间块中累积的时间与卵母细胞和胚胎计数呈负相关（所有p  < 0.05）。非工作日（≥ 7 小时）总屏幕时间较长的女性 在 COS 中获得 4.7 个卵母细胞（p  = 0.005）和 2.8 个胚胎（p = 0.008）。 PA 和 IVF 之前和期间的久坐行为不影响阳性 hCG 、临床妊娠和活产结果。

结论

我们的研究结果表明，在进入辅助生殖之前，在 PA 上花费的时间越长，在久坐行为上花费的时间越少，与更好的 COS 结果相关，而 IVF 之前和期间的活动水平不会影响植入、怀孕和活产结果。