Chemical substances shall not migrate from food contact materials (FCM) at levels that are potentially harmful for the consumers. Each of the current analytical methods applied to verify the migration of substances from FCM covers only one or few substances. There is a very limited number of publications on the development of analytical methods allowing the simultaneous determination of several classes of FCM substances, and almost none of them reported methods entirely dedicated to the ones in the positive list of Commission Regulation (EU) No. 10/2011 for plastic FCMs. Therefore, a simple, sensitive and reliable multi-analyte method was developed for the analysis of FCM substances in food simulants. It employs an optimised liquid-liquid extraction with dichloromethane as extraction solvent in the presence of 10% m/v NaCl, followed by quantitative analysis with gas chromatography coupled to mass spectrometry (GC-MS). A combination of total ion chromatograms (TICs) and extracted ion chromatograms (EICs) was used. The optimisation and validation of the method have been carried out according to current international guidelines. Adequate sensitivity was demonstrated in the selected concentration ranges for most of the analytes, with limits of quantification (LOQs) at least three times lower than the legislative limit, when existing. The results showed that the method is sufficiently accurate for the majority of substances, with recoveries between 70 and 115% and relative standard deviations (RSDs) smaller than 20% at three concentration levels. The method was applied to the analysis of some FCM multilayers. The method allows, for the first time, the simultaneous quantification of 84 FCM substances in two of the official food simulants (A and C) at levels of a few ng g⁻¹.

Graphical abstract

化学物质不得从食品接触材料（FCM）迁移到可能对消费者有害的水平。当前用于验证物质从FCM迁移的每种分析方法仅涵盖一种或几种物质。可以同时测定几种FCM物质的分析方法的出版物数量很少，几乎没有一种报告的方法完全适用于欧盟法规（EU）第10号肯定清单中的方法。 / 2011用于塑料FCM。因此，开发了一种简单，灵敏和可靠的多分析物方法来分析食品模拟物中的FCM物质。它在10％m / v NaCl，然后进行气相色谱-质谱联用（GC-MS）定量分析。使用了总离子色谱图（TIC）和提取的离子色谱图（EIC）的组合。该方法的优化和验证已根据当前的国际准则进行。对于所选的大多数分析物，在选定的浓度范围内显示出足够的灵敏度，并且定量限（LOQ）至少比法定限低三倍。结果表明，该方法对于大多数物质都足够准确，在三个浓度水平下的回收率在70％至115％之间，相对标准偏差（RSD）小于20％。该方法被应用于一些FCM多层膜的分析。该方法首次允许^-1。

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