BACKGROUND:Scallop shell powder is called bioshell calcium oxide (BiSCaO), which is known to possess deodorizing properties and broad antimicrobial activity against various pathogenic microbes, including viruses, bacteria, spores, and fungi. OBJECTIVE:This study aims to investigate the applicationsof BiSCaO suspension cleansing in clinical situations, for instance for the prevention and treatment of infections in chronic wounds in healing-impaired patients, without delaying wound healing. METHODS:The bactericidal activities of 1000 ppm BiSCaO suspension; 500 ppm hypochlorous acid; 1000 ppm povidone iodine; and saline were compared to evaluate in vivo disinfection and healing of Pseudomonas aeruginosa–infected wounds in hairless rats. RESULTS:Cleansing of the infected wounds with BiSCaO suspension daily for 3 days significantly enhanced wound healing and reduced the in vivo bacterial counts, in comparison to hypochlorous acid, povidone iodine, and saline. Furthermore, histological examinations showed significantly advanced granulation tissue and capillary formation in the wounds cleansed with BiSCaO suspension than in those cleansed with the other solutions. CONCLUSIONS:This study suggested that the possibility of using BiSCaO suspension as a disinfectant for infected wounds and limiting disinfection to 3 days may be sufficient to avoid the negative effects on wound repair.

中文翻译：

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生物壳氧化钙（BiSCaO）用于清洁和治愈无毛大鼠中铜绿假单胞菌感染的伤口。

背景：扇贝贝壳粉被称为生物贝壳氧化钙（BiSCaO），已知具有除臭性能和对多种病原微生物（包括病毒，细菌，孢子​​和真菌）的广泛抗菌活性。目的：本研究旨在探讨BiSCaO悬浮液清洗在临床情况下的应用，例如在不延迟伤口愈合的情况下，用于预防和治疗愈合受损患者的慢性伤口感染。方法：1000 ppm BiSCaO悬浮液的杀菌活性；500 ppm次氯酸; 1000 ppm聚维酮碘; 比较生理盐水和生理盐水，以评估铜绿假单胞菌感染的无毛大鼠的体内消毒和愈合情况。结果：与次氯酸，聚维酮碘和生理盐水相比，每天用BiSCaO悬浮液清洗感染的伤口3天，可显着增强伤口愈合并减少体内细菌数量。此外，组织学检查显示，用BiSCaO悬浮液清洗的伤口比其他溶液清洗的伤口肉芽组织和毛细血管形成明显改善。结论：这项研究表明，使用BiSCaO悬浮液作为感染伤口的消毒剂并将消毒时间限制为3天的可能性足以避免对伤口修复的负面影响。组织学检查显示，用BiSCaO悬浮液清洗后的伤口比其他溶液清洗后的肉芽组织和毛细血管形成明显改善。结论：这项研究表明，使用BiSCaO悬浮液作为感染伤口的消毒剂并将消毒时间限制为3天的可能性足以避免对伤口修复的负面影响。组织学检查显示，用BiSCaO悬浮液清洗后的伤口比其他溶液清洗后的肉芽组织和毛细血管形成明显改善。结论：这项研究表明，使用BiSCaO悬浮液作为感染伤口的消毒剂并将消毒时间限制为3天的可能性足以避免对伤口修复的负面影响。