Substituted hydroxamic acid is one of the most extensively studied pharmacophores because of their ability to chelate biologically important metal ions to modulate various enzymes, such as HDACs, urease, metallopeptidase, and carbonic anhydrase. Syntheses and biological studies of various classes of hydroxamic acid derivatives have been reported in numerous research articles in recent years but this is the first review article dedicated to their synthetic methods and their application for the synthesis of these novel molecules. In this review article, commercially available reagents and preparation of hydroxylamine donating reagents have also been described.

中文翻译：

---

异羟肟酸的合成方法

取代的异羟肟酸是研究最广泛的药效团之一，因为它们能够螯合生物学上重要的金属离子以调节各种酶，如 HDAC、脲酶、金属肽酶和碳酸酐酶。近年来，许多研究文章报道了各类异羟肟酸衍生物的合成和生物学研究，但这是第一篇致力于其合成方法及其在合成这些新分子中的应用的综述文章。在这篇评论文章中，还描述了市售试剂和羟胺捐赠试剂的制备。